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Showing 1–12 of 12 results
Advanced filters: Author: Zlatko Trajanoski Clear advanced filters

  • Filtered through the analytical power of artificial intelligence, the wealth of available biomedical data promises to revolutionize cancer research, diagnosis and care. In this Viewpoint, six experts discuss some of the challenges, exciting developments and future questions arising at the interface of machine learning and oncology.

    • Olga Troyanskaya
    • Zlatko Trajanoski
    • Nuria Oliver
    Reviews
    Nature Cancer
    Volume: 1, P: 149-152

  • Immune checkpoints blockade (ICB) is a viable anti-cancer strategy. Here the authors show that nuclear receptor NR2F6 acts as an immune checkpoint in T cells and, using mouse models and human T cells, they show NR2F6 inhibition might improve current ICB therapy or work as an alternative therapeutic strategy.

    • Victoria Klepsch
    • Natascha Hermann-Kleiter
    • Gottfried Baier
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Given the increasing use of immune-checkpoint inhibitors for treating cancer, immune-related adverse events — and markers to prevent and diagnose these — are coming into focus. A systematic analysis investigates genetic, molecular, cellular and clinical risk factors of such adverse events in a large pan-cancer cohort treated with multiple agents.

    • Dietmar Rieder
    • Zlatko Trajanoski
    News & Views
    Nature Cancer
    Volume: 4, P: 779-780

  • The cancer immunoediting hypothesis assumes the immune system sculpts the cancer genome. Here the authors show, in a mouse model, that neutral evolution outweighs the effects of immunoselection and that immune checkpoint blockade potentiates the immunoediting, switching the system to non-neutral evolution.

    • Mirjana Efremova
    • Dietmar Rieder
    • Zlatko Trajanoski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Cancer immunotherapies are promising strategies for cancer treatment. However, their optimized use will require a comprehensive understanding of the diverse cell types, antigens and genetic variants (both germline and somatic) that comprise the tumour–immune system interface. This Review discusses various bioinformatics tools that process multi-level omics data for insights into tumour–immune cell interactions.

    • Hubert Hackl
    • Pornpimol Charoentong
    • Zlatko Trajanoski
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 441-458

  • A study reporting the results of a clinical trial co-administering the GDF-15-blocking antibody visugromab with the anti-PD-1 antibody nivolumab demonstrates that neutralizing GDF-15 can overcome resistance to immune checkpoint inhibition in cancer.

    • Ignacio Melero
    • Maria de Miguel Luken
    • Eugen Leo
    ResearchOpen Access
    Nature
    Volume: 637, P: 1218-1227

  • Autophagy controls cellular homeostasis and influences immune responses. Galluzzi and colleagues show that tumor cell autophagy opposes inflammatory cell death following radiation therapy and can be inhibited to enhance antitumor responses.

    • Takahiro Yamazaki
    • Alexander Kirchmair
    • Lorenzo Galluzzi
    Research
    Nature Immunology
    Volume: 21, P: 1160-1171

  • The interactions between tumours and the immune system are highly complex. This article discusses methods — primarily computational tools — for characterizing diverse aspects of cancer–immune cell interactions, including antigen presentation, T cell repertoires and heterogeneity in cell types and cell states. The Review particularly highlights the insights from single-cell data from both sequencing technologies and in situ imaging of tissues.

    • Francesca Finotello
    • Dietmar Rieder
    • Zlatko Trajanoski
    Reviews
    Nature Reviews Genetics
    Volume: 20, P: 724-746

  • Pflügler, Svinka et al. identify a subset of Paneth cells in mouse intestinal crypts and tumors, which express the immune checkpoint molecule Ido1 in a Stat1-dependent manner and promote tumor growth. Gene expression data from human colorectal cancer (CRC) suggest that a similar population is present in human cancer and opens the door for further studies of immune escape mechanisms in CRC.

    • Sandra Pflügler
    • Jasmin Svinka
    • Robert Eferl
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-14