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Showing 1–23 of 23 results
Advanced filters: Author: Zoltan Arany Clear advanced filters

  • Evidence from mice and humans indicates that peripartum cardiomyopathy (PPCM) is a vascular disease caused by excessive anti-angiogenic signalling in the peripartum period of pregnancy and that pre-eclampsia and multiple gestation are important risk factors for the development of PPCM.

    • Ian S. Patten
    • Sarosh Rana
    • Zoltan Arany
    Research
    Nature
    Volume: 485, P: 333-338

  • The formation of new blood vessels from pre-existing ones is a carefully orchestrated dance. A study reveals that the metabolism of sugar by glycolysis contributes to its regulation.

    • Cholsoon Jang
    • Zoltan Arany
    News & Views
    Nature
    Volume: 500, P: 409-410

  • In ischaemic tissues, hypoxia and nutrient deprivation were found to induce the transcriptional regulator PGC-1α which in turn induces VEGF to promote angiogenesis; this pathway is independent of hypoxia-inducible factor, which is also implicated in hypoxia-induced VEGF regulation and angiogenesis.

    • Zoltan Arany
    • Shi-Yin Foo
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 451, P: 1008-1012

  • Elevated plasma branched-chain amino acid (BCAA) levels have been associated with insulin resistance and type 2 diabetes. Blair et al. show that altering BCAA oxidation in skeletal muscle or liver does not influence insulin sensitivity in male mice, despite the effects on BCAA plasma levels.

    • Megan C. Blair
    • Michael D. Neinast
    • Zoltan Arany
    Research
    Nature Metabolism
    Volume: 5, P: 589-606

  • Evidence from preclinical models suggest that lowering levels of branched chain amino acids (BCAA) improves glucose metabolism. Here the authors report that NaPB, an accelerator of BCAA catabolism, improves peripheral insulin sensitivity in patients with type 2 diabetes in a randomized placebo-controlled crossover clinical trial.

    • Froukje Vanweert
    • Michael Neinast
    • Esther Phielix
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • Nonalcoholic steatohepatitis (NASH) starts with lipid droplet accumulation in the liver that eventually causes inflammation and fibrosis. Here, authors use lipophagy activators to limit the accumulation of lipids in the liver and show that this can prevent disease progression in a mouse model of nonalcoholic steatohepatitis.

    • Yoshito Minami
    • Atsushi Hoshino
    • Satoaki Matoba
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Heart failure is a major cause of cardiovascular morbidity and mortality. Here, the authors report results of a genome-wide association study meta-analysis, characterizing the role of common genetic variants in heart failure, finding overlap with common cardiovascular risk factors and imaging measures of cardiac structure/function.

    • Michael G. Levin
    • Noah L. Tsao
    • Scott M. Damrauer
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Myofibroblast differentiation contributes to extracellular matrix remodeling and fibrosis. Here, the authors report that alterations in mitochondrial calcium uptake is essential for metabolic reprogramming and epigenetic signaling for activation of the myofibroblast gene program.

    • Alyssa A. Lombardi
    • Andrew A. Gibb
    • John W. Elrod
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • The oxidative pentose-phosphate pathway (oxPPP) is a major NADPH producer. Here the authors show that malic enzyme or isocitrate dehydrogenase can support the growth of cells lacking the oxPPP, but the oxPPP is necessary to maintain a normal NADPH/NADP ratio, DHFR activity and folate metabolism.

    • Li Chen
    • Zhaoyue Zhang
    • Joshua D. Rabinowitz
    Research
    Nature Metabolism
    Volume: 1, P: 404-415

  • Modulating the capacity of the intestinal epithelium to catabolize fructose is shown to alter fructose-induced lipogenesis in the mouse liver, suggesting that fructose clearance in the small intestine protects from steatosis.

    • Cholsoon Jang
    • Shogo Wada
    • Joshua D. Rabinowitz
    Research
    Nature Metabolism
    Volume: 2, P: 586-593

  • An understanding of how fat cells (adipocytes) develop will contribute to our understanding of obesity. The differentiation of committed preadipocytes into adipocytes is known to be controlled by PPARγ and several other transcription factors. But what turns a cell into a preadipocyte? Here, the zinc-finger protein Zfp423 is identified as a transcriptional regulator of preadipocyte determination.

    • Rana K. Gupta
    • Zoltan Arany
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 464, P: 619-623

  • The rationale behind chimaeric antigen receptor T cell therapy is reviewed, and current challenges in oncology, preliminary reports in noncancerous diseases and relevant emerging technologies are discussed.

    • Daniel J. Baker
    • Zoltan Arany
    • Carl H. June
    Reviews
    Nature
    Volume: 619, P: 707-715

  • Peripartum cardiomyopathy (PPCM) is a rare form of heart failure that presents in late pregnancy or early in the postpartum period. In this Review, Hoes and colleagues discuss the known risk factors for PPCM, including genetic variants and pre-eclampsia, and describe the potential pathogenic mechanisms underlying the development of PPCM such as disrupted metabolic homeostasis in the heart owing to pregnancy-induced hormone fluctuations.

    • Martijn F. Hoes
    • Zoltan Arany
    • Peter van der Meer
    Reviews
    Nature Reviews Cardiology
    Volume: 19, P: 555-565

  • Stereoselective production of trans-4-substituted cyclohexane-1-amines—including a key intermediate in the synthesis of antipsychotic drug cariprazine—remains challenging. Here, the authors develop a process catalyzed by a single transaminase to produce trans-4-substituted cyclohexane-1-amines from the corresponding cis/trans-diastereomeric mixtures via a cis-deamination approach in continuous-flow, to achieve a dynamic cis-to-trans isomerization.

    • Emese Farkas
    • Péter Sátorhelyi
    • János Éles
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-9

  • Here, Mark Tarnopolsky and colleagues propose that the systemic benefits of exercise are mediated by exosomes containing peptides and nucleic acids (exerkines) that act in an autocrine, paracrine and/or endocrine manner. They also discuss the therapeutic potential of using exerkine-enriched native or modified exosomes to treat metabolic diseases such as obesity and type 2 diabetes mellitus.

    • Adeel Safdar
    • Ayesha Saleem
    • Mark A. Tarnopolsky
    Reviews
    Nature Reviews Endocrinology
    Volume: 12, P: 504-517