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Checkpoint signalling blocks the cell cycle at specific transition points, checkpoints, to ensure that the events of the cell cycle take place in the correct order. Checkpoint signalling is also activated for example by damage to the DNA so that the cell cycle does not proceed until the damage is repaired.
High mobility group A1 (HMGA1) has been identified to play a role in tumour progression but its involvement in anti-tumour immunity of esophagael squamous cell carcinoma (ESCC) remains unclear. Here the authors report that the inhibition of STING-mediated anti-tumour immunity by HMGA1 results in promotion of ESCC tumorigenesis.
Intracellular copper concentration has been linked to cell proliferation. Here, the authors demonstrate that copper binding to both Cyclin-dependent kinase 1 (CDK1) and CCNB1 is essential for activating CDK1 and promoting the G2/M transition in the cell cycle.
David Barford discusses how the template model for MAD2 activation in the spindle assembly checkpoint represented a new concept for generating and propagating intracellular signals.
Proteins of the mitotic checkpoint regulate insulin receptor internalization through clathrin-mediated endocytosis, thereby modulating insulin signalling and systemic glucose metabolism.