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Methylation analysis is the study of chromosomal patterns of DNA or histone modification by methyl groups. The cytosine (C) base in DNA and lysine residue in histone tails can be methylated. Methylation constitutes an epigenetic mark because its ___location can affect the regulation of gene expression in a heritable fashion.
The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.
The role of germline variation in cancer remains underexplored. Here, the authors investigate the landscape of germline structural variants on tumour DNA methylation across pediatric brain and central nervous system tumour patients and suggest disease implications.
Germ layer specification during zygotic genome activation is regulated by chromatin state. Here, the authors use single-cell multiome profiling in Drosophila to show that H3K27me3 and H3K27ac at cis-regulatory elements control cell type-specific gene expression and developmental progression.
A metagenomic approach to identifying the sources of N6-methyldeoxyadenine (6mA) in eukaryotic DNA found no evidence of high 6mA abundances in sampled eukaryotes.
