Clinical trial design articles from across Nature Portfolio

Improving neuraminidase content of influenza vaccines is a major focus of vaccine development. Here the authors present safety and immunogenicity of seasonal influenza mRNA vaccine candidates simultaneously encoding hemagglutinin and neuraminidase antigens in a first in-human study.

Cherian et al. discuss the ICMR—Phase 1 Clinical Trial Network that has been established in India. The network envisages to build capacity for early phase clinical trials in the country focusing on the clinical development of leads which are of national health priority.

Liver transplantation is challenged by organ scarcity and ageing donors. Machine perfusion is a promising technique to enhance organ preservation and assessment, improving liver utilization and patient outcomes. Here, we discuss current practices in machine perfusion using the IDEAL framework and outline the steps needed to advance this technology clinically.