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Alzheimer disease: BACE1 branches out

Nature Medicine volume 12, page 1123 (2006)Cite this article

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The enzyme, BACE1 (beta-site amyloid precursor protein–cleaving enzyme 1), is required to cleave amyloid-β from a larger precursor. (After BACE1-mediated cleavage, the presenilin-containing complex γ-secretase makes the final cleavage, liberating amyloid-β.)

Michael Willem et al. found that BACE1 seems to be required for processing a signal, the EGF-like factor neuregulin 1,that activates receptors on Schwann cells. Activation of these receptors is required for myelination.

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  1. Charlotte Schubert
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Schubert, C. Alzheimer disease: BACE1 branches out. Nat Med 12, 1123 (2006). https://doi.org/10.1038/nm1006-1123

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