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A randomized phase 2a clinical trial of an AI-discovered drug and target combination for idiopathic pulmonary fibrosis shows safety and signs of efficacy, marking a concrete step forward in bringing AI-enabled drug discovery into the clinic.
A new analysis supports dietary guidelines to reduce the consumption of processed meat, sugar-sweetened beverages and trans-fatty acids — highlighting the need for a collaborative, meticulous health assessment framework for ultra-processed foods.
Widely spread around the globe, chikungunya virus (CHIKV) is a mosquito-borne virus that can cause severe acute disease, sometimes followed by debilitating chronic joint pain. This study provides estimates of the burden of CHIKV infection on public health for 180 countries and evaluates the potential benefits of vaccination campaigns.
Advances in beta cell differentiation have propelled cell therapies for diabetes into the clinic; this Review outlines the lessons learned from early-phase trials and discusses the clinical, manufacturing and regulatory challenges that must now be overcome.
To capture the changing rather than one-off risk of type 1 diabetes (T1D), we developed an artificial intelligence-driven microRNA-based multi-context (5,983 samples from 7 countries) dynamic risk score (DRS). We validated that this DRS enabled T1D discrimination, misdiagnosis correction and therapeutic response prediction, establishing a personalized, adaptive framework for T1D risk monitoring and intervention.
We developed CANSCAN, a blood test that analyzes multidimensional features of cell-free DNA (cfDNA) using whole-genome sequencing (WGS) and artificial intelligence (AI) models. This multi-cancer early detection (MCED) test demonstrates high sensitivity for early-stage cancers and accurate tissue-of-origin prediction in large prospective validation and asymptomatic screening cohorts.
A new study identifies a novel subset of mast cells that cross-present tumor antigens in patients triple-negative breast cancer — and a pilot clinical trial shows how these can be exploited in immunotherapy strategies.
Virtual reality sports offer a novel and effective strategy to reduce fat mass and holistically promote metabolic, physical, psychological and cognitive health in adolescents with excess body weight, yielding similar, and at times superior, benefits compared with conventional real-world sports.
Insights into TB heterogeneity are informing strategies for patient stratification and treatment shortening; this Perspective discusses the formidable challenge of treating this complex disease with strategies that can be implemented across global settings, for effective disease control.
A study provides much-needed data to support health system strengthening to combat antimicrobial resistance — for which climate change is acting as a catalyst — but more data and coordinated action on a global scale are urgently needed.
This Review summarizes the current knowledge on sources, types and health effects of synthetic chemical contaminants in foods, particularly ultra-processed foods, and discusses regulatory shortcomings and policy-relevant research needs.
A promising phase 1 trial with patients with refractory Hodgkin lymphoma underscores the potential value of allogeneic natural killer (NK) cell therapy guided by NK cell-specific engagers.
Integrating artificial intelligence into routine mammography screening for breast cancer can increase the number of breast cancers detected without increasing the number of women recalled for further evaluation of suspicious findings.
Over the past three decades, dietary iron deficiency has remained a persistent global health burden, with notable disparities across age, sex and regions. This study tracks global trends from 1990 to 2021, identifying high-risk populations and offering insights for targeted public health interventions.
The Response Assessment in Neuro-Oncology (RANO) group defines a standardized framework for amino acid PET imaging of brain metastases for use in clinical trials and eventually in clinical practice to facilitate development of novel therapies and improve patient care.
According to a large, cluster-randomized clinical trial, controlling blood pressure helps protect the brain from dementia — adding to previous results from this study demonstrating reductions in stroke, heart disease and mortality.
A randomized controlled trial of a family-focused intervention for children in care in England and Scotland takes a bold step in filling the gap in high-quality evaluation of child welfare, but novel trial designs will be required to truly know what is best for children.
An interdisciplinary analysis revealed that the 2022 mpox outbreak in New York City was initiated by dozens of introductions of mpox virus into New York City. Epidemic modeling suggests that infection of highly connected individuals in a heavy-tailed sexual contact network explains the rapid rise and fall of the outbreak.
This Review critically examines the evidence base in precision nutrition research, discusses the challenges in translating short-term studies into long-term clinical effectiveness and highlights the many opportunities that lie ahead.
SPIRIT 2025 provides updated guidance to authors, reviewers and editors, when preparing clinical trial protocols to enhance their transparency and completeness.
