A promising phase 1 trial with patients with refractory Hodgkin lymphoma underscores the potential value of allogeneic natural killer (NK) cell therapy guided by NK cell-specific engagers.
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References
Herrera, A. F. et al. N. Engl. J. Med. 391, 1379–1389 (2024).
Younes, A. et al. J. Clin. Oncol. 30, 2183–2189 (2012).
Gauthier, J. et al. Blood 137, 323–335 (2021).
Horwitz, S. et al. Lancet 393, 229–240 (2019).
Nieto, Y. et al. Nat. Med. https://doi.org/10.1038/s41591-025-03640-8 (2025).
Kerbauy, L. N. et al. Clin. Cancer Res. 27, 3744–3756 (2021).
Gauthier, L. et al. Cell 177, 1701–1713.e1716 (2019).
Giang, K. A. et al. Nat. Biotechnol. 77, 139–148 (2023).
Demaria, O. et al. Sci. Immunol. 9, eadp3720 (2024).
Bednarski, J. J. et al. Blood 139, 1670–1683 (2022).
Haroun-Izquierdo, A. et al. J. Immunother. Cancer 10, e005577 (2022).
Ghobadi, A. et al. Lancet 405, 127–136 (2025).
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K.-J.M. has received research support from Oncopeptides for work related to immune engagers. All relationships have been approved by Oslo University Hospital, University of Oslo, Norway and Karolinska Institute, Stockholm, Sweden.
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Sohlberg, E., Malmberg, KJ. The innate power of natural killer cells in cancer therapy. Nat Med 31, 1755–1756 (2025). https://doi.org/10.1038/s41591-025-03712-9
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DOI: https://doi.org/10.1038/s41591-025-03712-9