Table 2 Pregnancy outcomes among people with any laboratory evidence and a subset with nucleic acid amplification test (NAAT)-confirmed Zika virus infection - U.S. Zika Pregnancy and Infant Registry, U.S. States and DC.

From: Outcomes up to age 36 months after congenital Zika virus infection—U.S. states

 

Total n (%) N = 2374

NAAT-confirmed n (%) N = 423

Pregnancy outcome

2374

423

 Live births

2248 (94.7)

371 (87.7)

 Pregnancy loss

  <20 weeks’ gestation

96 (4.0)

39 (9.2)

  ≥20 weeks’ gestation

30 (1.3)

12 (2.8)

 Gestational age of outcomea

2213

364

  Term (≥37 weeks)

1987 (89.7)

325 (89.3)

  Preterm (<37 weeks)

226 (10.2)

39 (10.7)

  Missing

35 (1.6)

7 (1.9)

 Small-for-gestational agea,b

2139

354

  Overall

237 (11.1)

61 (17.2)

 Birth defectsa

2248

371

  Any Zika-associated birth defectsc

122 (5.4)

38 (10.0)

  Any eye abnormalities

28 (1.2)

10 (2.6)

  Eye abnormalities only (without brain abnormalities and/or microcephaly)

10 (0.4)

1 (0.3)

  Any brain abnormalities and/or microcephaly with or without eye abnormalities

112 (4.9)

37 (9.9)

  Brain abnormalities and/or microcephaly without eye abnormalities

94 (4.2)

28 (7.5)

  Microcephaly only without reported brain or eye abnormalitiesd

47 (2.1)

11 (2.9)

  Microcephaly only without reported brain or eye abnormalities & small-for-gestational agee

33 (70.2)

9 (81.8)

  Brain abnormalities without microcephaly or eye abnormalities

19 (0.8)

4 (1.1)

  Brain and/or microcephaly and eye abnormalities

18 (0.8)

9 (2.4)

 Infant and child deathf

1638

289

  Overall

20 (1.2)

5 (1.7)

  Neonatal (<28 days)

12 (60)

4 (80)

  Postneonatal infant (≥28 days to 364 days)

6 (30)

0 (0)

  Child (≥1 year)

2 (10)

1 (20)

  1. NAAT nucleic acid amplification test.
  2. aAmong live births.
  3. bDefined as weight <10th percentile for sex and gestational age according to INTERGROWTH-21st.
  4. cThe case definition for Zika-associated birth defects has been previously described.3,16
  5. dNeuroimaging was available for 76.6% (n = 36) and 100% (n = 11) of infants with microcephaly only from pregnancies with laboratory evidence of confirmed or possible Zika virus infection during pregnancy and NAAT-confirmed Zika virus infection, respectively.
  6. eNeuroimaging was available for 78.8% (n = 26) and 81.8% (n = 9) infants with only microcephaly reported and small-for-gestational age from pregnancies with laboratory evidence of confirmed or possible Zika virus infection during pregnancy and NAAT=confirmed Zika virus infection, respectively.
  7. fLimited to live born infants not lost to follow-up prior to 12 months of age.