Fig. 2: Shared and distinct MSN changes in NPS. | Translational Psychiatry

Fig. 2: Shared and distinct MSN changes in NPS.

From: Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson’s disease

Fig. 2

A NPS and nNPS both showed MSN changes relative to HPs. B Compared with nNPS, MSN of NPS significantly decreased in the DLPFC, somatomotor cortex and occipital cortex, with significantly decrease in SMN and VIS1 and increase in FPN based on network-level analysis (C). Decreased MSN in DMN were observed in anxiety and depression (D, E), while apathy, ICBs and hallucinations were characterized by decreased MSN in SMN and VIS1 (F–H). *p < 0.05, no corrected; **p < 0.05, FDR corrected. ICBs impulse compulsive behaviors, HPs healthy participants, MSN morphometric similarity network; NPS neuropsychiatric symptoms, nNPS with no neuropsychiatric symptoms, DLPFC dorsolateral prefrontal cortex, VIS1 primary visual network, VIS2 secondary visual network, SMN somatomotor network, CON cingulo-opercular network, DAN dorsal attention network, LAN language network, FPN frontoparietal network, AUD auditory network, DMN default mode network, PMM posterior multimodal network, VMM ventral multimodal network, ORA orbito-affective network.

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