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Clinical Studies

Advancing radiomics from contrast-enhanced mammography in breast cancer

British Journal of Cancer volume 132, pages 154–155 (2025)Cite this article

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TO THE EDITOR:

The clinical behavior and outcomes of breast cancer are significantly affected by its biological heterogeneity, which consists of both intertumoral and intratumoral heterogeneity (ITH) [1]. Quantitative measurement of ITH through radiomic analysis of tumor subregions is a promising approach [2]. We read with great interest the recent study by Wang et al. [3], which explored the utility of whole tumor and subregion-based radiomic features from contrast-enhanced mammography (CEM) in differentiating HER2 expression status in invasive breast cancers. The integration of whole tumor-based (wITH), subregion-based (sITH) ITH radiomics features, along with traditional radiological features, shows promise in improving the model’s ability to accurately differentiate the HER2 expression status. While the study provides valuable insights, there are several issues that warrant further clarification and exploration.

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Authors and Affiliations

  1. Department of Radiology, the First Affiliated Hospital of Jinan University, Guangzhou, China

    Xuewei Wu, Ye Ling, Shuixing Zhang & Bin Zhang

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  1. Xuewei Wu
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  2. Ye Ling
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  3. Shuixing Zhang
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  4. Bin Zhang
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Contributions

Xuewei Wu and Ye ling drafted and revised the manuscript. Bin Zhang and Shuixing Zhang conceived the project, supervised writing, and revised the manuscript. All authors read and approved the final version.

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Correspondence to Bin Zhang.

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Wu, X., Ling, Y., Zhang, S. et al. Advancing radiomics from contrast-enhanced mammography in breast cancer. Br J Cancer 132, 154–155 (2025). https://doi.org/10.1038/s41416-024-02932-z

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  • DOI: https://doi.org/10.1038/s41416-024-02932-z

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