Fig. 5: Products obtained by disulfuration of aldehydes and functionalization of natural compounds. | Nature Communications

Fig. 5: Products obtained by disulfuration of aldehydes and functionalization of natural compounds.

From: Decatungstate-catalyzed radical disulfuration through direct C-H functionalization for the preparation of unsymmetrical disulfides

Fig. 5

Isolated yields are provided. Reaction conditions: substrate 5 (0.3 mmol, 1.0 equiv.), tetrasulfide 3a (0.45 mmol, 1.5 equiv.), TBADT 2 mol%, Na2S2O8 (0.45 mmol, 1.5 equiv.), solvent 3 mL (CH3CN/H2O, v/v, 2/1), 390 nm, Ar, 60 °C, and 12 h. aReaction time: 4 h. If the reaction time is extended to 12 h, some of the products will decompose into aroylmonosulfides (see SI for details). bReaction conducted at room temperature. cWith tetrasulfide 3b (1.5 equiv.). dDetermined by 1H NMR spectroscopy. eReaction run in the absence of Na2S2O8 in 3 mL [CH3CN/(HCl aq. 1.0 M), v/v, 2/1]. fReaction conditions: substrate 5m (0.2 mmol, 1.0 equiv.), 5 h. gReaction conditions: substrate 5n (0.1 mmol, 1.0 equiv.), room temperature, 12 h.

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