Fig. 6: MDSC accumulation in the livers of chronic AE patients, uninfected mice, E. multilocularis-infected wild type and PD-1-deficient mice. | Nature Communications

Fig. 6: MDSC accumulation in the livers of chronic AE patients, uninfected mice, E. multilocularis-infected wild type and PD-1-deficient mice.

From: Targeting myeloid-derived suppressor cells promotes antiparasitic T-cell immunity and enhances the efficacy of PD-1 blockade

Fig. 6

a Flow cytometric gating strategy used to identify and integrate liver-infiltrating MDSCs, G-MDSCs and M-MDSCs from AE patients. b, c Percentage or absolute number of MDSCs, G-MDSCs and M-MDSCs in paired CLTs versus DLTs from AE patients (n = 11). d Representative flow cytometry plot of MDSCs, G-MDSCs and M-MDSCs in the livers of uninfected, wild-type (WT) or PD-1-/- mice at week 24 post-infection. e, f Percentage or absolute number of MDSCs, G-MDSCs and M-MDSCs in the livers of uninfected, WT or PD-1-/- mice at week 24 post-infection (n = 5). The data represent at least two independent experiments. b, c Data were analysed using two-tailed paired Student’s t tests. e, f Data were analysed using a one-way ANOVA with Tukey’s multiple comparisons test. All data are presented as the mean ± SD. n.s., P > 0.05. Source data are provided as a Source Data file.

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