Fig. 5: Reaction scale-up and one-pot substrate scope. | Nature Communications

Fig. 5: Reaction scale-up and one-pot substrate scope.

From: Photo-induced decarboxylative C-S bond formation to access sterically hindered unsymmetric S-alkyl thiosulfonates and SS-alkyl thiosulfonates

Fig. 5

a Gram-scale synthesis. b One-pot synthesis of  S-thiosulfonates and SS-thiosulfonates. Acid (0.22 mmol), NHPI (0.2 mmol), DCC (0.22 mmol), DMAP (0.02 mmol), rt, 5 h. aStandard condition A: 2 (2 equiv, 0.4 mmol), 4CzIPN (2 mol%, 0.004 mmol), Cu(OAc)2 (20 mol%, 0.04 mmol), KHCO3 (2 equiv, 0.4 mmol), EA (2 mL) at room temperature (rt), 5 W blue LEDs, 12 h in N2. bStardard condition B: 2 (2 equiv, 0.4 mmol), 4CzIPN (2 mol%, 0.004 mmol), Cu(OTf)2 (20 mol%, 0.04 mmol), (BuO)2P(O)OH (2 equiv, 0.4 mmol), EA (2 mL) at room temperature (rt), 5 W blue LEDs, 12 h in N2. EA ethyl acetate.

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