Fig. 6: Accelerated diabetic wound healing of porcine.

a Schematic illustration of the study design and the blood glucose levels of the Bama pigs. b Representative images of the wound area by different treatments after the operation (n = 6 biologically independent samples). Scale bar: 1 cm. c Quantification of relative wound areas on Day 3 and Day 18 after receiving different treatments (n = 6 biologically independent samples). d Quantification of relative wound volumes on Day 3 and Day 6 after receiving different treatments (n = 6 biologically independent samples). e H&E staining of wound tissues with different treatments on Day 18 (images are representative of 6 biologically independent samples). Blue arrow: inflammation; yellow arrow: necrobiosis; green arrow: panniculitis; white arrow: hemorrhage. Scale bar: 1 mm. f Semiquantitative analysis of wound healing through treatment-blinded pathohistological scoring of H&E and Masson images for granulation tissue, collagen deposition, epithelialization, and inflammation, yielding a cumulative wound healing score for each scaffold type tested (n = 6 biologically independent samples). All data were presented as the mean ± SEM. Statistical significance was determined using a one-way ANOVA test followed by Tukey’s multiple comparison analysis. Parts of a were created with BioRender.com.