Fig. 5: Mina53-mediated demethylation of H4R3me2a regulates genes involved in NSPC proliferation and differentiation. | Nature Communications

Fig. 5: Mina53-mediated demethylation of H4R3me2a regulates genes involved in NSPC proliferation and differentiation.

From: Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity

Fig. 5

a Volcano plot of differentially expressed genes (DEGs) in NSPCs in the presence or absence of Mina53 depletion (n = 3 for each group). b Gene set enrichment analysis of DEGs. c Venn diagram showing the overlapped genes with both increased H4R3me2a occupancy and altered gene expressions in the RNA-seq data. d Enrichment analyses of the upregulated and down-regulated DEGs in control or Mina53 cKO NSPCs. For statistics in this figure, the two-tail unpaired Student’s-t test was used in (a) and (b). Only genes and pathways whose P value are less than 0.05 and absolute value of log2FC are equivalent to or greater than 1.5 are used for further analysis. Scale bar, 50 μm. Source data are provided as a Source Data file and Supplementary Data 2.

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