Fig. 1: Ring opening of pyrazoles and our design strategy. | Nature Communications

Fig. 1: Ring opening of pyrazoles and our design strategy.

From: Transforming an azaarene into the spine of fusedbicyclics via cycloaddition-induced scaffold hopping of 5-Hydroxypyrazoles

Fig. 1

A Carbanion-induced ring opening of 3-carbonyl pyrazole series. B Pyrazolium ylide induced ring opening and rebound of 1H-pyrazole series. C Our working hypothesis of this work. D Representative biologic active compounds containing a similar scaffold of our desired product and our rational design. E Conceptual outlines for (a) ring expansion, (b) deconstructive functionalization, and (c) ring-upgrading.

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