Fig. 6: Brief treatment course with 1e and 2a reduces fungal burden in a mouse model of drug-resistant systemic candidiasis. | Nature Communications

Fig. 6: Brief treatment course with 1e and 2a reduces fungal burden in a mouse model of drug-resistant systemic candidiasis.

From: Structure-guided optimization of small molecules targeting Yck2 as a strategy to combat Candida albicans

Fig. 6

Neutropenic female CD1 mice were infected with C. albicans DPL15 (FKS1T1922C/FKS1T1922C) by lateral tail vein injection. Mice were dosed twice daily (50 mg/kg PO) for a total of four doses with either (a) 1e or (b) 2a. In other treatment groups, high dose caspofungin (4 mg/kg IP) once daily for a total of two doses, or a combination of 2a or 1e with caspofungin was given as indicated. Control groups received equal volumes of vehicles alone on the same schedule as the combination groups. Kidneys were resected 12 h after the final dose of test materials. Fungal burden from control and treatment groups is plotted as CFU per gram wet kidney weight (n = 6 mice/treatment group; Error bars represent the mean ± SD). Statistical significance was determined by one-way ANOVA with SIDAK’s multiple comparison adjustment. ****p < 0.0001; *** Vehicle vs 2a P-value = 0.0005, CF vs combination P-value = 0.0002, 2a vs combination P-value = 0.0007; ** Vehicle vs 1e P-value = 0.0082, CF vs combination P-value = 0.0013, 1e vs combination P-value = 0.0019. Source data are provided as a Source Data file.

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