Fig. 2: Crystal structure of the complex of human SENP5CD with SUMO1 and SUMO2.
From: Structural basis for the human SENP5’s SUMO isoform discrimination
a Cartoon representations of the SENP5CD-SUMO1 complex structure. SENP5 catalytic ___domain and SUMO1 are shown in orange and blue, respectively. The catalytic residues are labelled and depicted in stick representation. Secondary structure elements are labelled. N-terminal and C-terminal are marked. b Cartoon representations of the SENP5CD-SUMO2 complex structure. SENP5 catalytic ___domain and SUMO1 are shown in blue and green, respectively. The catalytic residues are labelled and depicted in stick representation. Secondary structure elements are labelled. N-terminal and C-terminal are marked. c Structural superimposition between SENP5CD-SUMO1 (blue) and SENP5CD-SUMO2 (green) complexes. SENP5CD is depicted as an electrostatic surface representation. d Structural alignment of sequences corresponding to the catalytic domains for human SENP2, SENP5 and SENP7. Red asterisks indicate interface residues with SUMO2. Catalytic triad residues are shown in red. Secondary structure cartoon is depicted above for SENP5 (green), SENP2 (violet) and SENP7 (brown). e Superposition of the SENP5CD structures (blue surface) in complex with SUMO1 (red) or SUMO2 (blue). Side chain interface residues are depicted in a stick representation.
