Fig. 4: The relationship between FERscore and tumor biological and microenvironment characteristics in breast cancers (METABRIC).
From: Efficacy of FERscore in predicting sensitivity to ferroptosis inducers in breast cancer
A Hallmark gene sets enriched in breast cancers with high- and low-FERscores. Correlation between FERscore and (B) stemness, (C) epithelial-mesenchymal transition (EMT), (D) EMT-related transcription factors, and (E) DNA damage and repair. F The Spearman correlation between the tumor microenvironment (TME) and FERscore. G Correlation between the FERscore and the abundance of specific infiltrated immune and stromal cells computed according to the xCell algorithm. H Differences in expression of immune checkpoints and co-stimulatory receptors between high- and low-FERscore groups. For (B, C, E), box plots indicate median; 25th and 75th percentiles; ***P < 0.001; ns, not significant (P > 0.05); two-tailed t-tests. For (D, F, H), box-and-whisker plots indicate median; 25th and 75th percentiles; whiskers, minima and maxima of the distributions; *P < 0.05; ***P < 0.001; ns, not significant (P > 0.05); the Wilcoxon signed rank test.
