Fig. 2: P-values by different SNPs of interest and AUCtau by rs2246709. | npj Breast Cancer

Fig. 2: P-values by different SNPs of interest and AUCtau by rs2246709.

From: Pharmacokinetics and pharmacogenomics of ribociclib in black patients with metastatic breast cancer the LEANORA study

Fig. 2

2A Genetic data were available for all 14 exploratory candidate gene analysis participants. Variants are plotted by p-value with a dotted line representing a p-value of 0.05. This exploratory analysis of 14 participants identified one variant with a p < 0.05 for ribociclib AUCTAU: CYP3A4 rs2246709 (p = 0.0041). 2B. This exploratory analysis identified an association between ribociclib area under the curve (AUC) in participants with a CYP3A4 variant (rs2246709), showing a higher AUC in those with A/G relative to those with A/A (p = 0.0041).

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