Fig. 3: Study design.

During screening, a swab CYP3A5 genotype was obtained to ensure adequate power. On C1D1, C1D8-16, and C2D1, blood counts and chemistries were obtained, as well as an electrocardiogram per standard of care. The list of concurrent medications was also obtained, and patients received a drug diary and patient-reported outcomes (CTCAE-PRO) questionnaires. Created with BioRender.com.