Fig. 2: GWAS meta-analysis of progression to Hoehn and Yahr stage 3 or greater (H&Y3+).
From: Genome-wide determinants of mortality and motor progression in Parkinson’s disease
Note that the loci in the Manhattan plot and the forest plots have been labelled with the physically closest genes, though these may not necessarily be the causal genes. a The Manhattan plot showing four GWAS significant loci after meta-analysis. The blue dashed line indicates the threshold for genome-wide significance, p = 5 × 10−8. SNPs highlighted in red have p-value < 5 × 10−9. SNPs highlighted in orange have p-value < 5 × 10−8. b Forest plot for the top SNP rs115217673 in Chromosome 1, in MORN1. c Forest plot for the top SNP rs145274312 in Chromosome 7, near ASNS. d Forest plot for the top SNP rs113120976 in Chromosome 4, near PDE5A. e Forest plot for the top SNP rs141421624 in Chromosome 2, in XPO1. BP Base Pair, CI Confidence Interval, GWAS Genome Wide Association Study. HR Hazard Ratio. SNP Single Nucleotide Polymorphism.
