Table 2 Top 10 independent SNPs from meta-analysis of progression to mortality
From: Genome-wide determinants of mortality and motor progression in Parkinson’s disease
chr | bp | rsID | effect allele | non-effect allele | effect allele freq | nearest gene | distance to gene (BP) | beta | SE | Hazard Ratio | 95% CI | p-value | p-value COJO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
19 | 45411941 | rs429358 | C | T | 0.160 | APOE | 0 | 0.295 | 0.046 | 1.342 | 1.23–1.47 | 1.35E−10 | 1.60E−10 |
7 | 139637422 | rs4726467 | T | C | 0.021 | TBXAS1 | 0 | 0.713 | 0.116 | 2.039 | 1.63–2.56 | 7.71E−10 | 8.49E−10 |
12 | 33635494 | rs10437796 | A | C | 0.098 | SYT10 | 42740 | 0.304 | 0.056 | 1.355 | 1.21–1.51 | 5.31E−08 | 5.76E−08 |
9 | 17616880 | rs3808753 | G | A | 0.035 | SH3GL2 | 0 | 0.448 | 0.088 | 1.564 | 1.32–1.86 | 3.34E−07 | 3.52E−07 |
3 | 113979619 | rs142285045 | A | C | 0.013 | ZNF80 | 23194 | 0.836 | 0.165 | 2.308 | 1.67–3.19 | 3.80E−07 | 4.06E−07 |
18 | 33965217 | rs76125680 | C | G | 0.012 | FHOD3 | 0 | 0.874 | 0.174 | 2.397 | 1.70–3.37 | 5.32E−07 | 5.65E−07 |
15 | 34896795 | rs35294489 | G | A | 0.014 | GOLGA8B | 20959 | 0.757 | 0.152 | 2.131 | 1.58–2.87 | 6.07E−07 | 6.43E−07 |
5 | 55533638 | rs28811891 | T | C | 0.026 | ANKRD55 | 4452 | 0.544 | 0.109 | 1.722 | 1.39–2.13 | 6.21E−07 | 6.49E−07 |
21 | 31807104 | rs145506557 | C | A | 0.016 | KRTAP13-4 | 4028 | 0.896 | 0.180 | 2.451 | 1.72–3.49 | 6.59E−07 | 7.27E−07 |
10 | 98786658 | rs17112311 | A | G | 0.049 | C10orf12 | 41073 | 0.364 | 0.074 | 1.439 | 1.25–1.66 | 8.07E−07 | 8.31E−07 |
