Fig. 2: Overall design of DBS loop mechanisms elucidated via fMRI.
From: Push-pull effects of basal ganglia network in Parkinson’s disease inferred by functional MRI
a The dataset employed in this study. b The idea of fMRI-driven multi-scale model construction, from expressing the microscopic neuronal level synaptic activity by the CBTC model to the mesoscopic cluster scale, and then connecting the Balloon model to the macroscopic level aim to generate BOLD signal, demonstrating the calculation of BOLD signal using neural activity in a specific region. c The fitting effect of the fMRI-driven multi-scale model, showing that the trend of model simulation is basically consistent with real data. fMRI = functional MRI; PD = Parkinson’s disease; HC = healthy controls; DBS-OFF = patients with PD with the deep brain stimulation switched off; DBS-ON = patients with PD with the deep brain stimulation switched on; GPe = globus pallidus externa; GPi = globus pallidus interna; STN = subthalamic nucleus; Th = thalamus; PY = pyramidal neuron; IN = interneuron; Cor = cortex.
