Extended Data Fig. 2: Azole susceptibility of WGS strains. | Nature Microbiology

Extended Data Fig. 2: Azole susceptibility of WGS strains.

From: Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris

Extended Data Fig. 2

Table listing selected evolved strains (numbers) and their respective ERG-genotype (details see Table 1). The four major membrane sterol alteration types (1-4) are indicated by numbered boxes on the left, colored based on the typical sterol present for that type (see Fig. 2). The heatmap on the left shows relative growth (%) in different concentrations of fluconazole (FLU) and posaconazole (POS) in a BDA assay, averaged over 2 technical repeats. The heatmaps on the right show the relative (to parental strain) FLU and POS resistance (RR), based on AUC and MIC as measured by BDA. # detailed information about the partial translocation of NCP1 in strain 14 can be found in Supplementary Fig. 3 (Supplementary). *Chr6 contains ERG27. **Chr4 contains ERG6, ERG2, ERG7 and ERG12.

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