Extended Data Fig. 3: Substrate scope of imines with primary/secondary/tertiary alkyl and methyl groups.
From: Asymmetric hydrogenation of ketimines with minimally different alkyl groups
aReaction conditions: 1 (0.25 mmol), Mn-17 (2 mol%) and NaHMDS (5 mol%) in PhF (0.5 mL) at 5 °C for 20 h. Isolated yields (%) were given and enantioselectivities (%ee) were determined by chiral-phase HPLC. bMn-15 was used instead of Mn-17 at 25 °C. cMn-6 was used instead of Mn-17 at 25 °C. dMn-1 (2 mol%) and NaOtBu (10 mol%) in 1,4-dioxane (0.8 mL) at 60 °C for 20 h. eMn-1 (2 mol%) and KOtBu (20 mol%) in diethylene glycol dimethyl ether (0.8 mL) at 25 °C.
