Extended Data Fig. 7: Dnmt3aR878H mutation decreases promoter methylation and increases expression of genes involved in mitochondrial respiration.
From: Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs
a, Normalized enrichment scores (NES) for the indicated gene sets from GSEA using genes ranked by differential promoter methylation or gene expression in the comparison between vehicle-treated Dnmt3aR878H/+ cells versus vehicle-treated Dnmt3a+/+ cells and between metformin treated Dnmt3aR878H/+ cells versus vehicle-treated Dnmt3aR878H/+ cells. b, Normalized enrichment scores (NES) for the indicated gene sets from GSEA using genes ranked by differential promoter methylation or gene expression in the comparison between DNMT3AR882-mutated versus DNMT3AWT HSPCs as pseudobulk populations in the GSE158067 dataset. GSEA was performed using all Gene Ontology (GO) gene sets. The top 10 enriched GO gene sets ranked based on NES from gene expression are shown. The ones shown in green color are related to mitochondrial respiration.
