Extended Data Fig. 9: DGAT2: Example of genome organization at a candidate immune-priming lncRNA locus.
From: A genome-wide association analysis reveals new pathogenic pathways in gout
ENCODE H3K4me3 signal track from CD14+ monocytes indicates enrichment at the promoters of DGAT2, the lncRNA RP11-535A19.2 and UVRAG. ENCODE CTCF signal track from neutrophils and CD14+ monocytes indicates CTCF binding at rs11236533. Genehancer connections are in green and illustrate physical connections (Hi-C) between rs11236533 which disrupts a CTCF site and additional maximally-associated SNPs at two Genehancer regulatory elements. Red and blue dots indicate the CpG locations that are associated with co-localized meQTL and the color denotes direction of effect of the gout risk allele (red = higher methylation, blue = lower methylation). White lollipops represent maximally-associated SNPs at the locus within predicted cis regulatory elements.
