Extended Data Fig. 6: Wnt10a is epigenetically altered in Brca1-HET AV cells and is associated with AP-1 and basal differentiation state. | Nature Genetics

Extended Data Fig. 6: Wnt10a is epigenetically altered in Brca1-HET AV cells and is associated with AP-1 and basal differentiation state.

From: Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer

Extended Data Fig. 6

a, Degree of conservation in sequence identity and span between the mouse (mm10) and human (hg38) genomes for the chromatin regions and genes that showed progressively increased accessibility from Gp1 to Gp2 to Gp3 cells and higher expression levels in tumor cells compared to AV cells, respectively. b, Spearman analysis showing genes with significant correlation (two-sided p < 0.05) with Wnt10a expression at a single-cell level within the tumor epithelial cell population in scRNA-seq data. Positively correlated genes in the AP-1 family, Wnt pathway, or the basal differentiation markers are highlighted. c, Violin plot showing expression levels of Wnt10a across the major mammary epithelial cell types and tumor cells in scRNA-seq data. (Abbreviations: AV, alveolar cells; HS, hormone-sensing cells; BA, basal myoepithelial cells).

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