Extended Data Fig. 5: Heritability of genes with an eQTL grouped by gene expression.
(A) Boxplots of heritability in TwinsUK for genes with zero to five or more eQTL signals. Boxplots are split into subgroups based on the quartile of gene expression in TwinsUK. The number of genes with 0, 1, 2, 3, 4 and 5+ eQTL signals per expression quantile are Q1 (2,589, 1,819, 839, 288, 117, 87), Q2 (1,696, 1,830, 1,221, 590, 242, 159), Q3 (1,295, 1,995, 1,378, 635, 236, 199), and Q4 (1,160, 1,923, 1,465, 687, 295, 209), respectively. Lowly expressed genes are in quartile 1 shown in white, while highly expressed genes are in quartile 4 shown in darkest blue. Boxplot center lines represent the median value, box limits represent the upper and lower quartiles, whiskers represent the 1.5x interquartile range, and the black circles represent outliers. The black line connects the median of the boxplots. (B) Boxplots of heritability for genes separated by gene expression quartile. Numbers are the median heritability values. Boxplots as in A, with addition of the kernel density plots. Quartiles Q1-Q4 contain 5,738 or 5,739 genes.
