Extended Data Fig. 1: IRF4 deletion in T cells, dendritic cells, or macrophages does not reduce melanoma metastasis.
From: IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis
(a) Representative image of lung metastasis in Irf4fl/fl and Irf4fl/flCd4-Cre mice 20 days post B16-F10 cell intravenous injection, and a graph showing percentage survival rates for the injected mice. n = 6 mice per group; ns, not significant. (b) Representative lung metastasis image (day 20 post B16-F10 cell injection) in Irf4fl/fl and Irf4fl/flLysM-Cre mice, and percentage survival rates. n = 7 mice per group; ns, not significant. (c) Percentage survival rates of Irf4fl/flCd11c-Cre and Irf4fl/fl mice post B16-F10 cell intravenous injection. n = 5 mice per group; ns, not significant. (d) Percentages of remaining CD3‒NK1.1+ cells within splenocytes of WT and Irf4–/– mice three days post anti-NK1.1 mAb (clone PK136) treatment. Results are representative of two or three independent experiments. Data were analyzed by a log-rank test.
