Extended Data Fig. 5: Cluster characterization of white matter OLs in control and ALSP samples.
From: Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity
a. UMAP plot of white matter OLs (re-cluster from the Oligo cluster in Extended Data Fig. 3d) from the integrated dataset. b. Donut plots showing nuclei distribution of each OL subset in control or ALSP samples. c. Nuclei frequency of each OL subsets across all samples. d. Venn diagrams of overlapping genes commonly upregulated in ALSP OLs from the white matter and ALSP OLs from all regions. e. Pan-cell type relative information flow showing signaling pathways identified in ALSP (in red) and control (blue) white matter cells from the CellChat analysis. f. Chord diagrams plotting FGF signaling strength with the senders and receivers with their predicted ligands and receptors from the CellChat analysis. The lines represent changes in ligand-receptor interaction strength. g. Circle plot showing directed interaction of selected signaling pathways between cell types from the CellChat analysis.
