Extended Data Fig. 7: Cluster characterization of white matter astrocytes in control and ALSP samples.
From: Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity
a. UMAP plot of the integrated dataset of white matter cells from ALSP and control brains. b. UMAP plot of astrocytes (re-cluster from the Astro cluster in Extended Data Fig. 3d) from the integrated dataset. c. Nuclei frequencies of each astrocyte subset across all samples. d. Dot plot showing expression of marker genes for each astrocyte subset. e. Volcano plot depicting DEGs in ALSP versus control astrocytes in the white matter. f. GO-MF enriched in astrocytes from ALSP individuals. g. GO-MF enriched in astrocytes from controls in comparison to ALSP.
