Extended Data Fig. 8: Cluster characterization of endothelial, stromal, and immune cells in control and ALSP samples.
From: Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity
a. Volcano plot depicting DEGs in ALSP versus control capillary blood endothelial cells (cBEC). b. Molecular function (MF) enriched in cBEC from ALSP (upper panel) or control (lower panel) individuals. c. IPA pathways predicted to be activated (upper panel) or inhibited (lower panel) in ALSP cBEC. d. UMAP plot of stromal cells re-cluster from the Stroma and Peri_Fibro clusters. e. Dot plot showing expression of marker genes for each stromal subset. f. Volcano plot depicting DEGs in ALSP versus control pericytes. g. Molecular Function (MF) enriched in perivascular fibroblasts from ALSP compared to controls. h. IPA of pathways predicted to be activated in ALSP pericytes. i. UMAP plots of immune cells re-cluster from the IMM clusters. j. Dot plot showing expression of marker genes for each immune cell subset. k. UMAP plots of immune cells from different individuals. l. Violin plots displaying the expression of selected genes in control and ALSP immune cells.
