Extended Data Fig. 9: Graphical presentation of the body of in vivo data.
From: ApoE attenuates unresolvable inflammation by complex formation with activated C1q
a, Pleiotropic impacts of single ApoE or single C1q molecules in brain as reported by others. Microglia cells are the major source of brain C1q. In response to Aβ plaques, resting microglia cells differentiate into plaque-associated microglia cells. Single actions of ApoE and C1q have been reported to be involved in multiple pathways as indicated in the Figure. Inactive C1q (yellow), activated C1q (red). b, Graphical presentation of the body of in vivo data. Three types of unresolvable inflammatory conditions were studied in 7 mouse models and in translational studies of human tissues, that is choroid plexus, aorta, and brain parenchyma.
