Extended Data Fig. 9: Results of Mendelian randomization analysis in women of genetic instruments for testosterone and SHBG on the outcome of Type 2 diabetes.
From: Using human genetics to understand the disease impacts of testosterone in men and women
Plots show effect on ln(odds) of Type 2 diabetes in women (y axes) of the following sex hormone genetic instruments in women (x axes; effect size in units). a) Total testosterone. b) Steiger filtered total testosterone. c) Bioavailable testosterone. d) Steiger filtered bioavailable testosterone. e) Testosterone specific cluster. f) Steiger filtered testosterone specific cluster. g) SHBG. h) Steiger filtered SHBG. i) SHBG specific cluster. j) Steiger filtered SHBG specific cluster. P-values and effect size estimates (indicated by lines) are from Egger (pink), IVW (blue), and median IV (red) Mendelian randomization analyses. Bars indicate 95% confidence interval around the point estimate for each genetic variant. Analyses are based on association statistics generated in a maximum of: total testosterone (including specific and Steiger filtered), n = 230,454; bioavailable testosterone (including Steiger filtered), n = 188,507; SHBG (including specific and Steiger filtered), n = 189,473; T2D, n = 17,790 cases and n = 243,645 controls. Numbers of genetic variants included in the analyses are given in Supplementary Table 21. SHBG = sex hormone binding globulin.
