Extended Data Fig. 5: Results of Mendelian randomization analysis in men of genetic instruments for testosterone and SHBG on the outcome of Type 2 diabetes.
From: Using human genetics to understand the disease impacts of testosterone in men and women
Plots show effect on ln(odds) of Type 2 diabetes (y axes) in men of the following sex hormone genetic instruments (x axes; effect size in units). a) Total testosterone. b) Steiger filtered total testosterone. c) Bioavailable testosterone. d) Steiger filtered bioavailable testosterone. e) Testosterone specific cluster. f) Steiger filtered testosterone specific cluster. g) SHBG. h) Steiger filtered SHBG. i) SHBG specific cluster. j) Steiger filtered SHBG specific cluster. P-values and effect size estimates (indicated by lines) are from Egger (pink), IVW (blue), and median IV (red) Mendelian randomization analyses. Bars indicate 95% confidence interval around the point estimate for each genetic variant. Analyses are based on association statistics generated in a maximum of: total testosterone (including specific and Steiger filtered), n = 194,453; bioavailable testosterone (including Steiger filtered), n = 178,782; SHBG (including specific and Steiger filtered), n = 180,726; T2D, n = 34,990 cases and n = 150,760 controls. Numbers of genetic variants included in the analyses are given in Supplementary Table 20. SHBG = sex hormone binding globulin.
