Extended Data Fig. 1: Recurrent mutation and copy number alterations (CNAs) of DLBCL. | Nature Medicine

Extended Data Fig. 1: Recurrent mutation and copy number alterations (CNAs) of DLBCL.

From: TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

Extended Data Fig. 1

a, Frequencies and type of mutations identified by deep targeted sequencing in 57 recurrently mutated genes in 347 DLBCL tumors. Genes significantly enriched in ABC-DLBCL and GCB-DLBCL are highlighted in blue and orange, respectively. Colored asterisks represent the pathways to which mutations belong. b, Significant (q-value<0.25) focal amplifications (red) and deletions (blue) identified by GISTIC 2.0 analysis (n = 338). Representative genes (functionally known in DLBCL, as well as other cancers) within significant GISTIC regions are annotated. Genes significantly enriched in ABC-DLBCL and GCB-DLBCL are highlighted in blue and orange, respectively. Colored asterisks represent the pathways to which CNAs belong.

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