Extended Data Fig. 2: Hemagglutination inhibition (HI) titers.

Hemagglutination inhibition titers against cH6/1N5 virus (a), pandemic H1N1 virus (c), avian-swine H1N1 virus (e) and H5N8 virus (g) as well as cH8/1N1 (I) and cH5/1N1 (k) vaccine strains. Faint lines indicate reactivity of different individuals; bold lines indicate geometric mean titers of the respective groups. Biologically independent samples; group 1: n = 19, group 2: n = 14, group 4: n = 15 groups 3 + 5: n = 13(3 + 10); examined in one independent experiment. Geometric mean fold induction of antibody titers based on data in a, c, e, g, i and k is shown in b, d, f, h, j and l.