Extended Data Fig. 3: Sensitivity and degree centrality of clusters.
From: Disease risk and healthcare utilization among ancestrally diverse groups in the Los Angeles region
(a) The relationship between identity-by-descent called with Shapeit4 + iLASH (x-axis) and Eagle + hap-ibd (y-axis). Each dot represents the total identity-by-descent sharing between one pair of individuals. (b) The consistency between the Louvain clusters that were identified with the Shapeit4 + iLASH approach (‘original’) and Eagle + hap-ibd (‘new’) approaches. For 10,000 random pairs of individuals, we assessed whether the pair remained in the same cluster in the new approach, or vice-versa. (c) The proportion of participants in the ‘new’ clusters in each of the original clusters. (d) The degree centrality distribution (node degree divided by the max possible degree in the cluster) of selected clusters from the final round of Louvain clustering for a cluster where nearly every individual in the cluster is connected to every other member of the cluster. (e) is an example of a cluster where individuals share some connections, but on average are less connected to each other, and (f) is an example where individuals are moderately connected to each other.
