Extended Data Table 2 Additional Efficacy Findings from Start of Intensive Lifestyle Intervention Lead-In (Week-12) to Week 72 (Efficacy Estimand)

From: Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial

  1. BMI, body mass index; DBP, diastolic blood pressure; ETD, estimated treatment difference; HbA1c, glycated hemoglobin; HDL-C, high-density lipoprotein cholesterol; IWQOL-Lite-CT, Impact of Weight on Quality of Life-Lite-Clinical Trials Version; LDL-C, low-density lipoprotein cholesterol; MTD, maximum tolerated dose (10 or 15 mg); SBP, systolic blood pressure; SF-36v2, Short Form-36 version 2 Health Survey acute form; VLDL-C, very low-density lipoprotein cholesterol. aThe SF-36v2 measures health-related quality of life and general health status. The SF-36v2 scores are norm-based scores, ie, scores transformed to a scale in which the 2009 US general population has a mean score of 50 and an SD of 10. An increase in score represents an improvement in health status. bThe IWQOL-Lite-CT measures weight-specific health-related quality of life. All items are rated on either a 5-point frequency scale (‘never’ to ‘always’) or a 5-point truth scale (‘not at all true’ to ‘completely true’). Scores are transformed to a scale of 0 to 100, with higher scores reflecting better levels of functioning.
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