Extended Data Fig. 5: Cumulative incidence of subsequent basal cell carcinoma among European ancestry childhood cancer survivors categorized by joint categories of PRS quintiles and binary radiotherapy (RT). | Nature Medicine

Extended Data Fig. 5: Cumulative incidence of subsequent basal cell carcinoma among European ancestry childhood cancer survivors categorized by joint categories of PRS quintiles and binary radiotherapy (RT).

From: Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors

Extended Data Fig. 5

Cumulative incidence of subsequent basal cell carcinoma among European ancestry childhood cancer survivors with follow-up starting at age 21 years. Joint categories were defined by quintiles of PRS among controls and binary RT categories. RT was categorized (RT low: RT < 1 Gray; RT high: RT ≥ 1 Gray) based on maximum skin RT dose (maximum delivered dose to any body region divided by two). Lines represent the cumulative incidence and shaded areas around each cumulative incidence curve represent the 95% confidence bands. Gray’s test was used to test for heterogeneity among the cumulative incidence curves for joint PRS-radiotherapy categories, with statistical significance defined as p < 0.05 in two-sided tests. The table beneath the figure shows the number of survivors at risk by joint category group at age 21 and at successive age decades.

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