Extended Data Fig. 9: Regional association plots of loci with female-specific colocalization signals. | Nature Medicine

Extended Data Fig. 9: Regional association plots of loci with female-specific colocalization signals.

From: Sex-specific genetic architecture of blood pressure

Extended Data Fig. 9

LocusZoom plots are shown for the BP sex-stratified GWAS and FMD GWAS23, SCAD GWAS26, and PE GWAS22, using 1000 G EUR as LD reference (r2 > 0.2), in a ±250 kb window. P value presented are two-tailed and un-adjusted. (a) The chromosome 9p21 CDKN2B-AS1 region, with a lead SNP rs1333047 in PP females and a lead SNP rs2383206 in FMD (LD r2 = 0.9). (b) The 4q32.1 MAP9/GUCY1A1(GUCY1A3) region, with the same lead SNP, rs17033041, in PP in females and in FMD (c) The 21q22.11 LINC00310 region lead SNP rs9305545 in DBP in females and a lead SNP of rs28451064 in SCAD or FMD (LD r2 = 0.81). (d) The 4q21.21 FGF5 region lead SNP rs11099097 in PP in females and lead SNP rs13125101 in PE (LD r2 = 0.95 for these two SNPs).

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