Extended Data Fig. 2: DBP gene-sex interaction TWAS analysis identified COL4A1. | Nature Medicine

Extended Data Fig. 2: DBP gene-sex interaction TWAS analysis identified COL4A1.

From: Sex-specific genetic architecture of blood pressure

Extended Data Fig. 2

Manhattan plots show gene-based transcriptome-wide association studies (TWAS) for DBP using genotype-sex summary statistics from the GEM program (Fig. 3c) based on a linear mixed model adjusted with BP-associated covariates. MAGMA software was used to map all SNPs to 19,184 protein coding genes based on genomic locations. P-values presented are unadjusted and from two-tailed tests. The red dashed line indicates the genome-wide significance threshold at P = 2.61 × 10−6, defined as P = 0.05/19184. Results are shown for (a) gene-sex interaction analysis with a matched sample size between sexes from UKB (Nmale=145,375 and Nfemale = 143,102) (b) gene-sex interaction analysis included all available UKB samples (Nmale=166,379 and Nfemale = 193,523).

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