Extended Data Fig. 3: Comparison of colocalization findings at sex-specific BP loci.

(a) Arterial cis-eQTL-associated genes (eGenes) colocalized (PP.H4 > 0.5) with female-specific, male-specific, or non-sex-specific BP-associated loci are summarized with Venn diagrams. (b) Frequencies of arterial eGenes colocalized (PP.H4 > 0.5) with sex-specific BP-associated regions were compared to non-sex-specific BP-associated regions using a Fisher’s exact test; the table presents a summary of all BP loci, either sex-specific or non-sex-specific. (c) Arterial eGenes for sex-specific BP loci with sex-biased colocalization are shown; These loci specifically colocalize with the combined-sex eQTL data in only one sex of the GWAS data, indicated by pp.abf.H4 > 50% in one sex and pp.abf.H4 < 50% in the other sex. (d) eGenes for GWAS loci exhibiting sex-specific associations and sex-biased expression in arterial tissues, based on the GTEx v8 sex-biased genes database; heatmap values represent the largest effect size of differential expression by sex (F-M) in aorta, coronary artery, and tibial artery, indicating the magnitude of female-biased (red) or male-biased (blue) regulation for each gene. Male-specific associated loci and female-specific associated loci are denoted as 1 and 2, respectively. Strong functional candidate genes are labeled through colocalization of GWAS and eQTL in (e). O: pp.abf.H4 > 0.9. o: pp.abf.H4 > 0.75. c: pp.abf.H4 > 0.5.