Extended Data Fig. 7: Hypothesis-inconsistent interactions in trial sMRI and [18F]-FDG PET Data. | Nature Medicine

Extended Data Fig. 7: Hypothesis-inconsistent interactions in trial sMRI and [18F]-FDG PET Data.

From: p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial

Extended Data Fig. 7

Drug group-by-time interactions from voxel-wise factorial mixed ANCOVA models assessing where decline in gray matter volumes (a) and glucose metabolism (b) is greater in the drug group (sMRI n = 127; PET n = 121) compared to the placebo group (sMRI n = 66; PET n = 62). Voxels exhibiting this effect are shown in yellow (post hoc t contrast; one-sided). Given the exploratory nature of the trial, all P values are uncorrected. Hypothesis-consistent interactions (that is, where drug treatment slowed progression of pathology) in sMRI and PET data are shown in Fig. 4. For both a) and b), the medial and lateral views shown on the left half of the figure correspond to the left hemisphere of the brain.

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