Extended Data Fig. 5: Longitudinal changes in cognitive data at 12-weeks.

Box plots show the raw change in cognitive test scores between study baseline and the 12-week visit in the placebo (salmon) and LM11A-31 (teal) groups. Black horizontal lines on the box plots represent the median of the distribution. Notches provide 95% confidence intervals of the median. The lower and upper hinges of the boxplot correspond to the first and third quartiles of the distribution, and the whiskers (vertical lines) extend from the hinge to the largest or smallest value, no further than ±1.5 times the interquartile range from the hinge. a) The between-group difference in longitudinal cognitive decline on the NTB was not significant (P = 0.156) according to a Wilcoxon rank sum test. b) Placebo and drug groups did not differ in their median change scores on the ADAS-Cog-13 (Wilcoxon rank sum P = 0.422). All statistics were performed two-sided and were not adjusted for multiple comparisons, given the exploratory nature of the study. ADAS13, ADAS-Cog-13.