Extended Data Fig. 5: HLA promiscuity (HLApr).
a, Bar chart representing overall response rate (ORR) (complete response: CR, partial response: PR, stable disease: SD, progressive disease: PD, not evaluable: NA), stratified by HLApr (dichotomized by optimal statistical cutoff determined on Leuven RWD cohort, also for panel b, c, d, e and f). Two-sided p-value as calculated by Fisher’s Exact test. b, c, Kaplan-Meier curve showing progression-free survival (PFS) (b) and overall survival (OS) (c) stratified by HLApr. d, Bar chart representing ORR stratified by HLApr. Two-sided p-value as calculated by Fisher’s Exact test. e, f, Kaplan-Meier curve showing PFS (e), and OS (f) stratified by HLApr. Hazard ratio (HR), 95% confidence interval and two-sides p-values as calculated by Cox proportional hazard models, both univariate (UVA) as well as multivariate (MVA) adjusting for age and IMDC risk group. g, h, Bar chart representing distribution of Fuhrman tumour grade (g) and sarcomatoid differentiation (h) stratified by HLA promiscuity. Two-sided p-value as calculated by Fisher’s Exact test. i, Scatter pie plot. Pies represent HLA alleles, with x-axis position representing difference in ORR in patients with HLA allele vs. patients without, and y-axis position representing allele promiscuity value. Pie chart represents types of antigens presented by a particular allele, wherein the size of the pie-chart represents number of HLA-antigen pairs. j, Scatter pie plot. Pies represent HLA alleles, with x-axis position representing HR as calculated by UVA Cox proportional hazard regression model with PFS after start of ICB, and y-axis position representing allele promiscuity value. Pie chart represents types of antigens presented by a particular allele, wherein the size of the pie-chart represents number of HLA-antigen pairs.
