Extended Data Fig. 6: Concordance between expression profiles of biopsies that are fibrotic, compared with grafts that will become fibrotic.

A. Scatter plot of association statistics between grafts that are fibrotic and grafts that will become fibrotic. Each point is a gene, where the R2 = 0.21, p < 0.0001. B. Scatter plot of association statistics between grafts that are fibrotic and grafts that will become fibrotic. A hypothesis test is performed in all 8 directions, and the top 10 genes in each direction are coloured. C. Dot plot of a two-sided Wilcoxon-rank sum test for pathways associated with biopsy proven fibrosis compared to stable functioning grafts. Each dot represents one reactome pathway where p-values were adjusted for multiple comparisons using the benjamini-hochberg correction. D. Dot plot of a two-sided Wilcoxon-rank sum test for pathways associated with stable functioning biopsies that became fibrotic compared with biopsies that remained stable. Each dot represents one reactome pathway where p-values were adjusted for multiple comparisons using the benjamini-hochberg correction.